Review article
KEY PLAYERS IN INNATE IMMUNE RECOGNITION OF VIRUS INFECTION IN MAMMALS AND FISH
2006, 64 (2) p. 65-74
I Jakovlić, Y. B. Zhang, Q.J. Wu, Jian-Fang Gui
Abstract
Viral infection of mammalian cells activates an innate antiviral immune response characterized by production of interferon and subsequent enhanced transcription of interferon–stimulated genes important for antiviral defense. Cells recognize viral infection through various pathogen–associated molecular patterns, of which dsRNA seems to be the most important. In mammals, several gene products are important in recognition of dsRNA: RIG–I, TLR3, PKR and mda–5. Recent research proved that fish possess most of the key elements in recognition of viral infection which indicates that these mechanisms are very similar and evolutionary conserved in vertebrates.
Keywords
interferons; viral infection; dsrna; pkr; rig–i; tlr3; mda–5